Understanding MRD Testing

• What is MRD testing, and why is it important for my treatment plan?
• How is MRD testing different from other routine blood or bone marrow tests?
• What methods are used for MRD testing (e.g., flow cytometry, next-generation sequencing)?
• Why are there different testing sensitivities? Why are all tests not 10-6?

Timing and Frequency

• When should I undergo MRD testing during my treatment journey?
• How often will MRD testing be repeated to monitor my response to treatment?

Test Results and Implications

• How do I read my MRD test results? Can you or a nurse break them down for me?
• What does it mean if my MRD test comes back positive or negative?
• How early can I expect an MRD negative test with my current treatment?
• How will my MRD status affect my ongoing treatment plan?
• How many consecutive MRD negatives would I need to consider a treatment change?
• If I go off maintenance therapy, how often would I still be monitored?
• Can MRD-negative status predict how long I might stay in remission?
• What numbers or trends on the test results should I be concerned about? Is it as simple as positive or negative, or does the number of cells matter?
• Should my treatment goal be to reach MRD negativity? 

Testing Procedures

• What does the MRD testing procedure involve? Is it painful or risky?
• Will you perform imaging to accompany my MRD testing?
• Is a bone marrow biopsy (BMB) necessary for my MRD testing? 
• Can we use a previous sample for BMB, or will I need a new one?
• Is there a way to minimize discomfort when receiving a bone marrow biopsy?
• Are there any side effects or risks associated with MRD testing?

Access and Cost

• Is MRD testing covered by my insurance plan?
• Are there any financial assistance programs if my insurance doesn’t cover it?

Clinical Trials and New Treatments

• Are there clinical trials available that use MRD status to guide treatment decisions?
• How does MRD testing influence decisions about stopping or continuing therapy?

Long-Term Management

• What happens if I remain MRD-positive after treatment?
• If I reach MRD-negative status, does it mean I am cured?